Epha8^tm1Bbd
Targeted Allele Detail

Summary

• Symbol: Epha8^tm1Bbd
• Name: Eph receptor A8; targeted mutation 1, Mariano Barbacid
• MGI ID: MGI:2182746
• Synonyms: ephA8/eek-
• Gene: Epha8 Location: Chr4:136656730-136684127 bp, - strand Genetic Position: Chr4, 69.05 cM
• Alliance: Epha8^tm1Bbd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:41127
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exon encoding the extracellular domain was replaced with sequence encoding the transmembrane domain of the human NTRK1 receptor followed by lacZ and neo genes. The deletion was designed to generate a chimeric protein in which the fibronectin type III-like domains were absent from the extracellular region, leaving only 116 carboxy terminal residues intact, and in which the entire cytoplasmic region was replaced by lacZ. LacZ activity was detected during embryonic stages and undetected during postnatal development. (J:41127)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Epha8 Mutation: 75 strains or lines available

References

• Original: J:41127 Park S, et al., Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptors. EMBO J. 1997 Jun 2;16(11):3106-14
• All: 1 reference(s)