Mzf1^tm1Ppp
Targeted Allele Detail

Summary

• Symbol: Mzf1^tm1Ppp
• Name: myeloid zinc finger 1; targeted mutation 1, Pier Paolo Pandolfi
• MGI ID: MGI:2182764
• Synonyms: Mzf1^-
• Gene: Mzf1 Location: Chr7:12776230-12788691 bp, - strand Genetic Position: Chr7, 7.73 cM
• Alliance: Mzf1^tm1Ppp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70407
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of the coding region of the gene containing the DNA-binding domain and the first 11 zinc finger domains was replaced with a PGK-neo cassette in the opposite orientation via homologous recombination. Homozygous mutant animals lacked gene expression as shown by RT-PCR analysis of bone marrow cells. (J:70407)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Mzf1^tm1Ppp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mzf1 Mutation: 39 strains or lines available

References

• Original: J:70407 Gaboli M, et al., Mzf1 controls cell proliferation and tumorigenesis. Genes Dev. 2001 Jul 1;15(13):1625-30
• All: 1 reference(s)