F7^tm1Pec
Targeted Allele Detail

Summary

• Symbol: F7^tm1Pec
• Name: coagulation factor VII; targeted mutation 1, Peter Carmeliet
• MGI ID: MGI:2182766
• Synonyms: FVII-
• Gene: F7 Location: Chr8:13076034-13085809 bp, + strand Genetic Position: Chr8, 5.73 cM
• Alliance: F7^tm1Pec page

Hemorrhage and edema in F7^tm1Pec/F7^tm1Pec Proc^tm1Fjc/Proc^tm1Fjc mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:44294
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region for the mature protein, contained by exons 2 through 8, was replaced with a neomycin selection cassette. Northern blot analysis of total hepatic RNA showed an absence of transcript in homozygous mutant mice. An assay of procoagulation detected no such activity in homozygous mutant mice. (J:44294)

Expression

In Mice Carrying this Mutation:	62 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any F7 Mutation: 28 strains or lines available

References

• Original: J:44294 Rosen ED, et al., Mice lacking factor VII develop normally but suffer fatal perinatal bleeding. Nature. 1997 Nov 20;390(6657):290-4
• All: 9 reference(s)