Agfg1^tm1Jvd
Targeted Allele Detail

Summary

• Symbol: Agfg1^tm1Jvd
• Name: ArfGAP with FG repeats 1; targeted mutation 1, Jan M A van Deursen
• MGI ID: MGI:2182772
• Synonyms: Hrb^-
• Gene: Agfg1 Location: Chr1:82817204-82878903 bp, + strand Genetic Position: Chr1, 42.55 cM, cytoband C5
• Alliance: Agfg1^tm1Jvd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72756
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 500 bp region of the gene was replaced with a promoter-less IRES-lacZ-neo cassette via homologous recombination resulting in disruption of the gene at amino acid 108. Absence of gene expression in various tissues from homozygous mutant animals was verified by Western blot analysis. (J:72756)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Agfg1 Mutation: 46 strains or lines available

References

• Original: J:72756 Kang-Decker N, et al., Lack of acrosome formation in hrb-deficient mice. Science. 2001 Nov 16;294(5546):1531-3
• All: 5 reference(s)