Enpep^tm1Mdc
Targeted Allele Detail

Summary

• Symbol: Enpep^tm1Mdc
• Name: glutamyl aminopeptidase; targeted mutation 1, Max D Cooper
• MGI ID: MGI:2182774
• Synonyms: APA^-, BP-1^-
• Gene: Enpep Location: Chr3:129062824-129126369 bp, - strand Genetic Position: Chr3, 57.92 cM
• Alliance: Enpep^tm1Mdc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47424
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Portions of exon 1 and intron 1 were replaced by a neomycin selection cassette. Normal protein was undetected in homozygous mutant mice via flow cytometric analysis of bone marrow cells and staining of kidney sections. An assay of bone marrow cell culture supernatents showed no aberrant secretion of any protein product that could have been produced by targeted allele. Assays of renal cells, intestinal enterocytes, and stimulated bone marrow cells confirmed the ablation of aminopeptidase activity. (J:47424)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Enpep Mutation: 70 strains or lines available

References

• Original: J:47424 Lin Q, et al., T and B cell development in BP-1/6C3/aminopeptidase A-deficient mice. J Immunol. 1998 May 15;160(10):4681-7
• All: 7 reference(s)