Nfatc3^tm1Glm
Targeted Allele Detail

Summary

• Symbol: Nfatc3^tm1Glm
• Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3; targeted mutation 1, Laurie H Glimcher
• MGI ID: MGI:2182778
• Synonyms: c3-, c3-KO, NFAT4^-, nfatc3^-, Nfatc4 -
• Gene: Nfatc3 Location: Chr8:106785472-106857169 bp, + strand Genetic Position: Chr8, 53.08 cM, cytoband D
• Alliance: Nfatc3^tm1Glm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50124
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encoding the DNA-binding domain, encoding amino acids 535 through 592, was replaced with a neomycin selection cassette. Encoded protein was undetected via Western blot analysis of thymus protein extracts obtained from homozygous mutant mice. (J:50124)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nfatc3 Mutation: 71 strains or lines available

References

• Original: J:50124 Oukka M, et al., The transcription factor NFAT4 is involved in the generation and survival of T cells. Immunity. 1998 Sep;9(3):295-304
• All: 38 reference(s)