Ets1^tm2Jml
Targeted Allele Detail

Summary

• Symbol: Ets1^tm2Jml
• Name: E26 avian leukemia oncogene 1, 5' domain; targeted mutation 2, Jeffrey M Leiden
• MGI ID: MGI:2182780
• Synonyms: Ets-1^-, Ets1 KO
• Gene: Ets1 Location: Chr9:32547517-32669116 bp, + strand Genetic Position: Chr9, 17.97 cM
• Alliance: Ets1^tm2Jml page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50627
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A region encompassing all of exon 3 and a portion of exon 4 was deleted by the insertion of a neomycin selection cassette. Neither normal nor truncated protein was detected via Western blot analysis of splenocyte protein extracts obtained from homozygous mutant mice. (J:50627)

Expression

In Mice Carrying this Mutation:	16 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ets1 Mutation: 28 strains or lines available

References

• Original: J:50627 Barton K, et al., The Ets-1 transcription factor is required for the development of natural killer cells in mice. Immunity. 1998 Oct;9(4):555-63
• All: 24 reference(s)