Ets1^tm1Jml
Targeted Allele Detail

Summary

• Symbol: Ets1^tm1Jml
• Name: E26 avian leukemia oncogene 1, 5' domain; targeted mutation 1, Jeffrey M Leiden
• MGI ID: MGI:2182789
• Synonyms: Ets-1^-, Ets-1^p
• Gene: Ets1 Location: Chr9:32547517-32669116 bp, + strand Genetic Position: Chr9, 17.97 cM
• Alliance: Ets1^tm1Jml page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77869
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A region encompassing all of exon 3 and a portion of exon 4 was deleted by the insertion of a neomycin selection cassette. Encoded protein was undetected via immunoblot analysis of protein extracts from homozygous mutant thymocytes. Subsequent western blot analysis has determined that 1% to 5% of endogenous levels of a protein lacking the Point domain is expressed. (J:77869, J:125056)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ets1 Mutation: 28 strains or lines available

References

• Original: J:77869 Muthusamy N, et al., Defective activation and survival of T cells lacking the Ets-1 transcription factor. Nature. 1995 Oct 19;377(6550):639-42
• All: 9 reference(s)