Stom^tm1Wcm
Targeted Allele Detail

Summary

• Symbol: Stom^tm1Wcm
• Name: stomatin; targeted mutation 1, William C Mentzer
• MGI ID: MGI:2182798
• Gene: Stom Location: Chr2:35203998-35226988 bp, - strand Genetic Position: Chr2, 23.53 cM, cytoband B-C1
• Alliance: Stom^tm1Wcm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54046
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 637 base pair region, containing the putative promoter and the translational start codon, was replaced with a human growth hormone polyA-signal and a neomycin selection cassette. Encoded protein was undetected by immunoblotting of red blood cell samples obtained from homozygous mutant mice. (J:54046)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stom Mutation: 24 strains or lines available

References

• Original: J:54046 Zhu Y, et al., Stomatocytosis is absent in stomatin-deficient murine red blood cells. Blood. 1999 Apr 1;93(7):2404-10
• All: 2 reference(s)