Entpd1^tm1Rdr
Targeted Allele Detail

Summary

• Symbol: Entpd1^tm1Rdr
• Name: ectonucleoside triphosphate diphosphohydrolase 1; targeted mutation 1, Robert D Rosenberg
• MGI ID: MGI:2182811
• Synonyms: cd39^-
• Gene: Entpd1 Location: Chr19:40600810-40730046 bp, + strand Genetic Position: Chr19, 34.25 cM
• Alliance: Entpd1^tm1Rdr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57505
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1, containing the translational start codon, was replaced with a neomycin selection cassette. Neither transcript nor protein was detected in homozygous mutant mice via Northern and Western blot analyses. (J:57505)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Entpd1 Mutation: 35 strains or lines available

References

• Original: J:57505 Enjyoji K, et al., Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation [see comments]. Nat Med. 1999 Sep;5(9):1010-7
• All: 58 reference(s)