Phlda1^tm1Ywc
Targeted Allele Detail

Summary

• Symbol: Phlda1^tm1Ywc
• Name: pleckstrin homology like domain, family A, member 1; targeted mutation 1, Yongwon Choi
• MGI ID: MGI:2182815
• Synonyms: TDAG51^-
• Gene: Phlda1 Location: Chr10:111342147-111344506 bp, + strand Genetic Position: Chr10, 58.7 cM
• Alliance: Phlda1^tm1Ywc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72947
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region (exon 1) was replaced with a neomycin resistance gene via homologous recombination. Northern blot analysis of liver RNA from homozygous mutant animals confirmed the absence of gene expression. (J:72947)

Expression

In Mice Carrying this Mutation:

1 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Phlda1 Mutation: 9 strains or lines available

References

• Original: J:72947 Rho J, et al., TDAG51 Is Not Essential for Fas/CD95 Regulation and Apoptosis In Vivo. Mol Cell Biol. 2001 Dec;21(24):8365-70
• All: 8 reference(s)