Lepr^db-NCSU
Spontaneous Allele Detail

Summary

• Symbol: Lepr^db-NCSU
• Name: leptin receptor; diabetes, North Carolina State University
• MGI ID: MGI:2182820
• Gene: Lepr Location: Chr4:101574601-101672549 bp, + strand Genetic Position: Chr4, 46.96 cM
• Alliance: Lepr^db-NCSU page

Mutation origin

• Strain of Origin: CD-1

Mutation description

• Allele Type: Spontaneous
• Mutation: Intragenic deletion
• Mutation details: Sequence analysis of the NCSU allele revealed a single nucleotide deletion in exon 12 . This deletion results in a shift of the reading frame, causing a substitution of 11 amino acids followed by a premature termination of the protein prior to the membrane spanning domain. (J:60363)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lepr Mutation: 122 strains or lines available

References

• Original: J:60363 Brown JA, et al., Spontaneous mutation in the db gene results in obesity and diabetes in CD-1 outbred mice. Am J Physiol Regul Integr Comp Physiol. 2000 Feb;278(2):R320-30
• All: 1 reference(s)