Tnfrsf13b^tm1Vmd
Targeted Allele Detail

Summary

• Symbol: Tnfrsf13b^tm1Vmd
• Name: tumor necrosis factor receptor superfamily, member 13b; targeted mutation 1, Vishva M Dixit
• MGI ID: MGI:2182823
• Synonyms: TACI^-
• Gene: Tnfrsf13b Location: Chr11:61017581-61040198 bp, + strand Genetic Position: Chr11, 37.96 cM
• Alliance: Tnfrsf13b^tm1Vmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70172
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The region of the gene encoding the transmembrane domain and intracellular domain was replaced with a PGK-neo cassette via homologous recombination. The absence of gene expression in homozygous mutant animals was verified by Northern blot analysis of total spleen RNA. (J:70172)

Disease models

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfrsf13b Mutation: 18 strains or lines available

References

• Original: J:70172 Yan M, et al., Activation and accumulation of B cells in TACI-deficient mice. Nat Immunol. 2001 Jul;2(7):638-43
• All: 6 reference(s)