Tnfrsf21^tm1Ddy
Targeted Allele Detail

Summary

• Symbol: Tnfrsf21^tm1Ddy
• Name: tumor necrosis factor receptor superfamily, member 21; targeted mutation 1, Derek D Yang
• MGI ID: MGI:2182829
• Synonyms: DR6^-
• Gene: Tnfrsf21 Location: Chr17:43327446-43400079 bp, + strand Genetic Position: Chr17, 19.69 cM, cytoband C
• Alliance: Tnfrsf21^tm1Ddy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70594
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3, which include the translation initiation site, were replaced with a PGK-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was demonstrated by Northern blot analysis of kidney RNA using a cDNA probe to exon 4. (J:70594)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfrsf21 Mutation: 61 strains or lines available

References

• Original: J:70594 Liu J, et al., Enhanced CD4+ T cell proliferation and Th2 cytokine production in DR6-deficient mice. Immunity. 2001 Jul;15(1):23-34
• All: 3 reference(s)