Acsl4^tm1Tty
Targeted Allele Detail

Summary

• Symbol: Acsl4^tm1Tty
• Name: acyl-CoA synthetase long-chain family member 4; targeted mutation 1, Tokuo T Yamamoto
• MGI ID: MGI:2182854
• Synonyms: ACS4^-
• Gene: Acsl4 Location: ChrX:141100989-141173531 bp, - strand Genetic Position: ChrX, 63.12 cM
• Alliance: Acsl4^tm1Tty page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70023
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into exon 2, which is the first coding exon. Immunoblotting of hemizygous mutant ES cells showed an absence of protein. (J:70023)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acsl4 Mutation: 16 strains or lines available

References

• Original: J:70023 Cho YY, et al., Abnormal uterus with polycysts, accumulation of uterine prostaglandins, and reduced fertility in mice heterozygous for acyl-CoA synthetase 4 deficiency. Biochem Biophys Res Commun. 2001 Jun 22;284(4):993-7
• All: 1 reference(s)