Hip1^tm1Tsr
Targeted Allele Detail

Summary

• Symbol: Hip1^tm1Tsr
• Name: huntingtin interacting protein 1; targeted mutation 1, Theodora S Ross
• MGI ID: MGI:2182862
• Synonyms: HIP1^-
• Gene: Hip1 Location: Chr5:135435385-135573974 bp, - strand Genetic Position: Chr5, 75.18 cM, cytoband F-G2
• Alliance: Hip1^tm1Tsr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72637
• Parent Cell Line: RW1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 13.7 kb region spanning from exon 2 to exon 7 was replaced with a loxP-flanked neomycin resistance cassette via homologous recombination. Absence of gene expression was verified in brain and testicular extracts of homozygous mutant animals by Western blot analysis using a monoclonal antibody directed against a portion of the protein deleted by the gene targeting event. Phenotypic analysis in J:90400 suggests that this allele may be a hypomorph. (J:72637, J:90400)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hip1 Mutation: 67 strains or lines available

References

• Original: J:72637 Rao DS, et al., Huntingtin Interacting Protein 1 Is a Clathrin Coat Binding Protein Required for Differentiation of late Spermatogenic Progenitors. Mol Cell Biol. 2001 Nov;21(22):7796-806
• All: 4 reference(s)