Adcyap1tm1Aba
Targeted Allele Detail
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Symbol: |
Adcyap1tm1Aba |
Name: |
adenylate cyclase activating polypeptide 1; targeted mutation 1, Akemichi Baba |
MGI ID: |
MGI:2182878 |
Synonyms: |
Adcyaptm1Mok, PACAP- |
Gene: |
Adcyap1 Location: Chr17:93506448-93513967 bp, + strand Genetic Position: Chr17, 60.67 cM
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Alliance: |
Adcyap1tm1Aba page
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Germline Transmission: |
Earliest citation of germline transmission:
J:72576
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Parent Cell Line: |
E14TG2a (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The gene was disrupted by replacement of the 5' portion of exon 5 with a PGK-neo cassette via homologous recombination. RT-PCR analysis using primers to exons 3-4 and exons 3-5 did not detect gene expression in the midbrain and diencephalons of homozygous mutant animals. In situ hybridization of parasagittal brain sections from homozygous mutants using a probe to the deleted portion of the gene did not detect gene expression. The null allele was further demonstrated by radioimmunoassay (RIA) of brain samples from homozygous mutant animals, which did not detect protein product.
(J:72576)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Adcyap1 Mutation: |
22 strains or lines available
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Phenotypic Similarity to Human Syndrome: non-Sjogren's type aqueous-deficient dry eye syndrome J:240066.
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Original: |
J:72576 Hashimoto H, et al., Altered psychomotor behaviors in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP). Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13355-60 |
All: |
64 reference(s) |
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