Faah^tm1Crv
Targeted Allele Detail

Summary

• Symbol: Faah^tm1Crv
• Name: fatty acid amide hydrolase; targeted mutation 1, Benjamin F Cravatt
• MGI ID: MGI:2182901
• Synonyms: FAAH^-
• Gene: Faah Location: Chr4:115853866-115876034 bp, - strand Genetic Position: Chr4, 53.08 cM
• Alliance: Faah^tm1Crv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70666
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 and approximately 2kb of upstream sequence were replaced by a PGK-neo selection cassette. Western blot analysis of brain and liver protein extracts and immunofluorescence analysis of cerebral sections showed an absence of encoded protein in homozygous mutant mice. Assays using labeled substrate showed significant reductions (50-100 fold) of hydrolytic activity in homozygous mutant mice. (J:70666)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Faah Mutation: 28 strains or lines available

References

• Original: J:70666 Cravatt BF, et al., Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase. Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9371-6
• All: 72 reference(s)