Hivep2^tm1Sis
Targeted Allele Detail

Summary

• Symbol: Hivep2^tm1Sis
• Name: human immunodeficiency virus type I enhancer binding protein 2; targeted mutation 1, Shunsuke Ishii
• MGI ID: MGI:2182914
• Synonyms: Shn-2^-
• Gene: Hivep2 Location: Chr10:13841819-14027118 bp, + strand Genetic Position: Chr10, 5.14 cM, cytoband A2
• Alliance: Hivep2^tm1Sis page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72249
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 0.9 kb region of the gene encoding amino acids 1-1713 and containing the N-terminal zinc finger cluster was replaced with a neomycin resistance cassette via homologous recombination. Western blot analysis of T cells from homozygous mutant animals using monoclonal antibodies directed against amino acids 2287-2500 did not detect protein expression. (J:72249)

Disease models

Expression

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Hivep2 Mutation: 109 strains or lines available

References

• Original: J:72249 Takagi T, et al., Murine Schnurri-2 is required for positive selection of thymocytes. Nat Immunol. 2001 Nov;2(11):1048-53
• All: 14 reference(s)