Cnr1^tm1.1Ltz
Targeted Allele Detail

Summary

• Symbol: Cnr1^tm1.1Ltz
• Name: cannabinoid receptor 1; targeted mutation 1.1, Beat Lutz
• MGI ID: MGI:2182924
• Synonyms: CB1-, CB1^null, CB1R^-
• Gene: Cnr1 Location: Chr4:33924593-33948831 bp, + strand Genetic Position: Chr4, 16.28 cM
• Alliance: Cnr1^tm1.1Ltz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77936
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: This allele was generated by breeding mice heterozygous for Cnr1^tm1Ltz with transgenic mice ubiquitously expressing cre recombinase. Southern blot analysis showed that the entire open reading frame was removed, leaving a single loxP site and the FLP-recombinase target (FRT) flanked neo transgene in the single exon at this locus. A lack of transcript was determined via in situ hybridization of homozygous mutant embyros. (J:77936)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cnr1 Mutation: 42 strains or lines available

References

• Original: J:77936 Marsicano G, et al., The endogenous cannabinoid system controls extinction of aversive memories. Nature. 2002 Aug 1;418(6897):530-4
• All: 96 reference(s)