Slc18a2^tm1Kmo
Targeted Allele Detail

Summary

• Symbol: Slc18a2^tm1Kmo
• Name: solute carrier family 18 (vesicular monoamine), member 2; targeted mutation 1, Katrin A Mooslehner
• MGI ID: MGI:2182931
• Synonyms: GB1/1
• Gene: Slc18a2 Location: Chr19:59249328-59284444 bp, + strand Genetic Position: Chr19, 54.64 cM
• Alliance: Slc18a2^tm1Kmo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70606
• Parent Cell Line: CGR8 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 and flanking intronic sequences were replaced with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant neonates was demonstrated by RT-PCR analysis of total midbrain RNA using primers to exons 2 and 12. (J:70606)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc18a2 Mutation: 29 strains or lines available

Notes

ES cell line = CGR8.8 (subline of CGR8)

References

• Original: J:70606 Mooslehner KA, et al., Mice with very low expression of the vesicular monoamine transporter 2 gene survive into adulthood: potential mouse model for parkinsonism. Mol Cell Biol. 2001 Aug;21(16):5321-31
• All: 2 reference(s)