Gcdh^tm1Dmk
Targeted Allele Detail

Summary

• Symbol: Gcdh^tm1Dmk
• Name: glutaryl-Coenzyme A dehydrogenase; targeted mutation 1, David M Koeller
• MGI ID: MGI:2182942
• Synonyms: Gcdh-
• Gene: Gcdh Location: Chr8:85613022-85620550 bp, - strand Genetic Position: Chr8, 41.28 cM
• Alliance: Gcdh^tm1Dmk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77874
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Coding sequences in exon 1 were fused in-frame to a lacZ gene followed by a neomycin resistance cassette, which also replaced the 3' end of exon 1 through exon 7. A beta-galactosidase protein was expressed from this allele under the control of the endogenous promoter. (J:77874)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gcdh Mutation: 19 strains or lines available

References

• Original: J:77874 Koeller DM, et al., Biochemical, pathologic and behavioral analysis of a mouse model of glutaric acidemia type I. Hum Mol Genet. 2002 Feb 15;11(4):347-57
• All: 25 reference(s)