Il10rb^tm1Agt
Targeted Allele Detail

Summary

• Symbol: Il10rb^tm1Agt
• Name: interleukin 10 receptor, beta; targeted mutation 1, Michael Aguet
• MGI ID: MGI:2182946
• Synonyms: CRFB4^-, IL-10^-, IL-10R2^-
• Gene: Il10rb Location: Chr16:91203166-91222718 bp, + strand Genetic Position: Chr16, 52.87 cM
• Alliance: Il10rb^tm1Agt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:45917
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first two exons, encoding 39 amino acids including the signal peptide, were replaced with a neomycin cassette. Northern blot analysis of homozygous mutant ES cells showed an absence of transcript. (J:45917)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il10rb Mutation: 17 strains or lines available

References

• Original: J:45917 Spencer SD, et al., The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor. J Exp Med. 1998 Feb 16;187(4):571-8
• All: 39 reference(s)