Hrh2^tm1Wtn
Targeted Allele Detail

Summary

• Symbol: Hrh2^tm1Wtn
• Name: histamine receptor H2; targeted mutation 1, Takeshi Watanabe
• MGI ID: MGI:2182949
• Synonyms: H2R -, Hrh2^tm1Wat
• Gene: Hrh2 Location: Chr13:54346148-54390199 bp, + strand Genetic Position: Chr13, 28.4 cM
• Alliance: Hrh2^tm1Wtn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62871
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced most of the coding region of the gene including the translation initiation codon. RT-PCR analysis confirmed that no detectable transcript was expressed from this allele in stomach or brain of homozygous mice. (J:62871)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Hrh2 Mutation: 26 strains or lines available

References

• Original: J:62871 Kobayashi T, et al., Abnormal functional and morphological regulation of the gastric mucosa in histamine H2 receptor-deficient mice. J Clin Invest. 2000 Jun;105(12):1741-9
• All: 18 reference(s)