About   Help   FAQ
Hrh2tm1Wtn
Targeted Allele Detail
Summary
Symbol: Hrh2tm1Wtn
Name: histamine receptor H2; targeted mutation 1, Takeshi Watanabe
MGI ID: MGI:2182949
Synonyms: H2R -, Hrh2tm1Wat
Gene: Hrh2  Location: Chr13:54346148-54390199 bp, + strand  Genetic Position: Chr13, 28.4 cM
Alliance: Hrh2tm1Wtn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:62871
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced most of the coding region of the gene including the translation initiation codon. RT-PCR analysis confirmed that no detectable transcript was expressed from this allele in stomach or brain of homozygous mice. (J:62871)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Hrh2 Mutation:  26 strains or lines available
References
Original:  J:62871 Kobayashi T, et al., Abnormal functional and morphological regulation of the gastric mucosa in histamine H2 receptor-deficient mice. J Clin Invest. 2000 Jun;105(12):1741-9
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/10/2024
MGI 6.24
The Jackson Laboratory