Hrh1^Bphs-r
Spontaneous Allele Detail

Summary

• Symbol: Hrh1^Bphs-r
• Name: histamine receptor H1; B pertussis induced histamine sensitization, resistant
• MGI ID: MGI:2182954
• Synonyms: Bphs^h
• Gene: Hrh1 Location: Chr6:114374897-114459432 bp, + strand Genetic Position: Chr6, 53.05 cM
• Alliance: Hrh1^Bphs-r page

Mutation origin

• Strain of Origin: C3H/HeJ or CBA/J

Mutation description

• Allele Type: Spontaneous
• Mutation: Nucleotide substitutions
• Mutation details: This allele confers resistance to Bordetella pertussis induced histamine sensitization and occurs in strains C3H/HeJ and CBA/J. These strains carry three concordant amino acid changes in the predicted protein sequence (L263P, M313V and S331P) that are in the third intracellular loop and are postulated to be associated with signal transduction function. (J:77938)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Hrh1 Mutation: 36 strains or lines available

Notes

Mice homozygous for this allele do not die from hypotensive and hypovolemic shock induced by vasoactive amine challenge after pertussis toxin sensitization (J:77938).

References

• Original: J:4933 Sudweeks JD, et al., Locus controlling Bordetella pertussis-induced histamine sensitization (Bphs), an autoimmune disease-susceptibility gene, maps distal to T-cell receptor beta-chain gene on mouse chromosome 6. Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3700-4
• All: 4 reference(s)