Cacna1g^tm1Hssh
Targeted Allele Detail

Summary

• Symbol: Cacna1g^tm1Hssh
• Name: calcium channel, voltage-dependent, T type, alpha 1G subunit; targeted mutation 1, Hee-Sup Shin
• MGI ID: MGI:2182962
• Synonyms: alpha1G^-, Cav3.1^-
• Gene: Cacna1g Location: Chr11:94299217-94365024 bp, - strand Genetic Position: Chr11, 58.9 cM
• Alliance: Cacna1g^tm1Hssh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70557
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exon encoding N-terminal residues 82-118 was replaced with a neomycin resistance gene via homologous recombination. Western blot analysis of brain membrane fractions from homozygous mutant animals did not detect protein product. Whole cell voltage clamp analysis of thalamocortical relay neurons from homozygous mutants detected no calcium current thus confirming the functional ablation of the protein. (J:70557)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacna1g Mutation: 104 strains or lines available

References

• Original: J:70557 Kim D, et al., Lack of the burst firing of thalamocortical relay neurons and resistance to absence seizures in mice lacking alpha(1G) T-type Ca(2+) channels. Neuron. 2001 Jul 19;31(1):35-45
• All: 35 reference(s)