B3galnt1^tm1Led
Targeted Allele Detail

Summary

• Symbol: B3galnt1^tm1Led
• Name: UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 1; targeted mutation 1, Philip Leder
• MGI ID: MGI:2183036
• Synonyms: Brainiac 1 null
• Gene: B3galnt1 Location: Chr3:69481491-69506293 bp, - strand Genetic Position: Chr3, 32.24 cM
• Alliance: B3galnt1^tm1Led page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70591
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a PGK-neo cassette 140 bp downstream of the ATG start codon via homologous recombination, resulting in the deletion of the entire C-terminal region after amino acid 47 in the encoded protein. Genotype analysis detected homozygous mutant embryos at 3.5 days post coitum. No homozygous mutant animals could be recovered. (J:70591)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any B3galnt1 Mutation: 22 strains or lines available

References

• Original: J:70591 Vollrath B, et al., A Murine Homologue of the Drosophila brainiac Gene Shows Homology to Glycosyltransferases and Is Required for Preimplantation Development of the Mouse. Mol Cell Biol. 2001 Aug;21(16):5688-97
• All: 2 reference(s)