Affected Systems |
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cardiovascular system
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√
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decreased heart ventricle muscle contractility
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√
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decreased heart rate
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√
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prolonged QRS complex duration
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√
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cellular
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√
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abnormal intestinal goblet cell morphology
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√
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abnormal enterocyte proliferation
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√
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digestive/alimentary system
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√
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abnormal intestinal mucosa morphology
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√
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abnormal intestinal goblet cell morphology
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√
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decreased small intestinal villus height
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√
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abnormal enterocyte physiology
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√
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abnormal enterocyte proliferation
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√
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endocrine/exocrine glands
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√
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decreased activity of thyroid gland
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√
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growth/size/body
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√
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decreased body weight
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√
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postnatal growth retardation
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√
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hematopoietic system
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√
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decreased osteoclast cell number
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√
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abnormal osteoclast physiology
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√
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homeostasis/metabolism
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√
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√
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√
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decreased circulating thyroxine level
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√
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√
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increased circulating thyroxine level
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√
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increased circulating triiodothyronine level
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√
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decreased circulating insulin-like growth factor I level
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√
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decreased circulating thyroid-stimulating hormone level
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√
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increased circulating thyroid-stimulating hormone level
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√
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abnormal enzyme/coenzyme activity
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√
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abnormal response/metabolism to endogenous compounds
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√
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√
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immune system
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√
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decreased osteoclast cell number
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√
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abnormal osteoclast physiology
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√
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limbs/digits/tail
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√
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short tibia
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√
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short limbs
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√
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short tail
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√
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muscle
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√
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decreased heart ventricle muscle contractility
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√
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skeleton
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√
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skeleton phenotype
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N
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abnormal osteoclast physiology
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√
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short tibia
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√
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abnormal long bone epiphyseal plate morphology
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√
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decreased width of hypertrophic chondrocyte zone
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√
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increased long bone epiphyseal plate size
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√
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abnormal bone structure
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√
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decreased osteoclast cell number
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√
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decreased compact bone thickness
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√
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abnormal trabecular bone morphology
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√
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increased trabecular bone thickness
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√
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increased bone mass
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√
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osteosclerosis
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√
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delayed endochondral bone ossification
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√
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abnormal chondrocyte physiology
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√
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