Ppp1r1b^tm1Aaf
Targeted Allele Detail

Summary

• Symbol: Ppp1r1b^tm1Aaf
• Name: protein phosphatase 1, regulatory inhibitor subunit 1B; targeted mutation 1, A A Feinberg
• MGI ID: MGI:2183150
• Synonyms: DARPP32^-, DARPP-32 KO
• Gene: Ppp1r1b Location: Chr11:98239232-98248622 bp, + strand Genetic Position: Chr11, 61.75 cM
• Alliance: Ppp1r1b^tm1Aaf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78045
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 0.4kb of sequence, including the translational start codon, was replaced with a neomycin selection cassette. Normal protein was undetected in homozygous mutant mice by immunoblotting and immunocytochemistry. (J:78045)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppp1r1b Mutation: 18 strains or lines available

References

• Original: J:78045 Fienberg AA, et al., DARPP-32: regulator of the efficacy of dopaminergic neurotransmission. Science. 1998 Aug 7;281(5378):838-42
• All: 25 reference(s)