Prkcz^tm1Jmos
Targeted Allele Detail

Summary

• Symbol: Prkcz^tm1Jmos
• Name: protein kinase C, zeta; targeted mutation 1, Jorges Moscat
• MGI ID: MGI:2183160
• Synonyms: PKCzeta-, zetaPKC^-
• Gene: Prkcz Location: Chr4:155344586-155445818 bp, - strand Genetic Position: Chr4, 86.17 cM, cytoband E2
• Alliance: Prkcz^tm1Jmos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72720
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of a coding exon with a lacZ-neo cassette via homologous recombination. Absence of gene expression was demonstrated by Western blot analysis of various tissues from homozygous mutant animals. (J:72720)

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Prkcz^tm1Jmos

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkcz Mutation: 43 strains or lines available

References

• Original: J:72720 Leitges M, et al., Targeted Disruption of the zetaPKC Gene Results in the Impairment of the NF-kappaB Pathway. Mol Cell. 2001 Oct;8(4):771-80
• All: 28 reference(s)