Gabra2^tm1Uru
Targeted Allele Detail

Summary

• Symbol: Gabra2^tm1Uru
• Name: gamma-aminobutyric acid type A receptor subunit alpha 2; targeted mutation 1, Uwe Rudolph
• MGI ID: MGI:2183161
• Synonyms: alpha2(H101R), mutant allele 1
• Gene: Gabra2 Location: Chr5:71115735-71253192 bp, - strand Genetic Position: Chr5, 37.59 cM
• Alliance: Gabra2^tm1Uru page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65100
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: A point mutation was introduced into codon 101 (exon 4) resulting in the substitution of histidine with arginine (H101R). The targeting vector also contained a floxed neomycin cassette in intron 3 for selection. Mice carrying this allele were bred with transgenic mice expressing cre recombinase to generate Gabra2^tm1.1Uru. (J:65100)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gabra2 Mutation: 36 strains or lines available

References

• Original: J:65100 Low K, et al., Molecular and neuronal substrate for the selective attenuation of anxiety. Science. 2000 Oct 6;290(5489):131-4
• All: 5 reference(s)