Ephb4^tm1And
Targeted Allele Detail

Summary

• Symbol: Ephb4^tm1And
• Name: Eph receptor B4; targeted mutation 1, David J Anderson
• MGI ID: MGI:2183162
• Synonyms: EphB4^taulacZ
• Gene: Ephb4 Location: Chr5:137348371-137372784 bp, + strand Genetic Position: Chr5, 76.38 cM
• Alliance: Ephb4^tm1And page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57908
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A tau-lacZ-PGK-neo cassette replaced exon 1 and was fused in frame to the translation start codon via homologous recombination. Homozygous mutant embryos were identified by PCR genotyping at E9.5. (J:57908)

Expression

In Mice Carrying this Mutation:	58 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ephb4 Mutation: 43 strains or lines available

References

• Original: J:57908 Gerety SS, et al., Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development. Mol Cell. 1999 Sep;4(3):403-14
• All: 27 reference(s)