Neurog1^tm1And
Targeted Allele Detail

Summary

• Symbol: Neurog1^tm1And
• Name: neurogenin 1; targeted mutation 1, David J Anderson
• MGI ID: MGI:2183171
• Synonyms: ngn1^-, Ngn1^GFP
• Gene: Neurog1 Location: Chr13:56398291-56399976 bp, - strand Genetic Position: Chr13, 30.06 cM
• Alliance: Neurog1^tm1And page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46668
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exon containing the entire coding region of the gene was replaced with a GFP-PGK-neo cassette via homologous recombination. In situ hybridization analysis of E10.5 embryos demonstrated the absence of gene expression in homozygous mutants. GFP transcripts were detected in mutant animals in a pattern indistinguishable from the endogenous mRNA but no fluorescent signal could be detected. (J:46668)

Expression

In Mice Carrying this Mutation:	245 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Neurog1 Mutation: 19 strains or lines available

References

• Original: J:46668 Ma Q, et al., neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia. Neuron. 1998 Mar;20(3):469-82
• All: 46 reference(s)