Hdac1^tm1Sei
Targeted Allele Detail

Summary

• Symbol: Hdac1^tm1Sei
• Name: histone deacetylase 1; targeted mutation 1, Christian Seiser
• MGI ID: MGI:2183177
• Gene: Hdac1 Location: Chr4:129409897-129436506 bp, - strand Genetic Position: Chr4, 63.26 cM
• Alliance: Hdac1^tm1Sei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76941
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ and neo cassette replaced a portion of exon 5 and all of exons 6 and 7. The deleted region encoded the deacetylase consensus motif. Western blot analysis of whole cell extracts from homozygous mutant ES cells showed an absence of protein. (J:76941)

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hdac1 Mutation: 38 strains or lines available

References

• Original: J:76941 Lagger G, et al., Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression. EMBO J. 2002 Jun 3;21(11):2672-81
• All: 2 reference(s)