Ror2^tm1Ymi
Targeted Allele Detail

Summary

• Symbol: Ror2^tm1Ymi
• Name: receptor tyrosine kinase-like orphan receptor 2; targeted mutation 1, Yasuhiro Minami
• MGI ID: MGI:2183225
• Synonyms: mRor2^-, Ror2-
• Gene: Ror2 Location: Chr13:53263353-53440160 bp, - strand Genetic Position: Chr13, 27.68 cM, cytoband B3
• Alliance: Ror2^tm1Ymi page

Ror2^Y324C/Ror2^Y324C and Ror2^tm1Ymi/Ror2^tm1Ymi mice exhibit short tails at E10.75

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60125
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exons encoding an Ig-like domain with a neomycin resistance gene via homologous recombination. Western blot analysis confirmed the absence of protein expression in neural progenitor cells from homozygous mice. (J:60125, J:182150)

Disease models

Expression

In Mice Carrying this Mutation:	72 assay results
In Structures Affected by this Mutation:	35 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ror2 Mutation: 125 strains or lines available

References

• Original: J:60125 Takeuchi S, et al., Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation. Genes Cells. 2000 Jan;5(1):71-8
• All: 31 reference(s)