Egr2^tm3Pch
Targeted Allele Detail

Summary

• Symbol: Egr2^tm3Pch
• Name: early growth response 2; targeted mutation 3, Patrick Charnay
• MGI ID: MGI:2183227
• Synonyms: Egr2^f, Egr-2^flox, Krox20^floxneo
• Gene: Egr2 Location: Chr10:67371305-67378018 bp, + strand Genetic Position: Chr10, 34.96 cM, cytoband B5
• Alliance: Egr2^tm3Pch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75128
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: The second exon, which encodes the DNA-binding domain, was flanked by a single loxP site 5' to the exon and a loxP flanked neomycin selection cassette 3' to the gene. This allele is thought to be hypomorphic. (J:75128)

Expression

In Mice Carrying this Mutation:	2 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 8 strains available Cell Lines: 0 lines available
• Carrying any Egr2 Mutation: 33 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Aortic Valve Disease J:230306.

References

• Original: J:75128 Taillebourg E, et al., Conditional, floxed allele of the Krox20 gene. Genesis. 2002 Feb;32(2):112-3
• All: 34 reference(s)