Tacr1^tm1Rhn
Targeted Allele Detail

Summary

• Symbol: Tacr1^tm1Rhn
• Name: tachykinin receptor 1; targeted mutation 1, Rene Hen
• MGI ID: MGI:2183231
• Gene: Tacr1 Location: Chr6:82379315-82537085 bp, + strand Genetic Position: Chr6, 35.94 cM, cytoband D1
• Alliance: Tacr1^tm1Rhn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77640
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted at the translational start codon, resulting in the deletion of the first two transmembrane domains. The absence of encoded protein was determined by in situ hybridization and immunohistochemistry. (J:77640)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tacr1 Mutation: 40 strains or lines available

References

• Original: J:77640 Santarelli L, et al., Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1912-7
• All: 2 reference(s)