Nrp2^tm1Mkl
Targeted Allele Detail

Summary

• Symbol: Nrp2^tm1Mkl
• Name: neuropilin 2; targeted mutation 1, Michael Klagsbrun
• MGI ID: MGI:2183238
• Synonyms: NP2^-, Nrp2 KO, Nrp2-lacZ
• Gene: Nrp2 Location: Chr1:62742476-62857851 bp, + strand Genetic Position: Chr1, 31.35 cM, cytoband C2
• Alliance: Nrp2^tm1Mkl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75477
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 and part of the downstream intron were replaced with a lacZ-neo cassette via homologous recombination. Northern blot analysis using a cDNA probe to nucleotides 15-620 confirmed the absence of gene expression in E9.5 homozygous mutant embryos. (J:75477)

Expression

In Mice Carrying this Mutation:

13 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nrp2 Mutation: 89 strains or lines available

References

• Original: J:75477 Takashima S, et al., Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis. Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3657-62
• All: 10 reference(s)