Cyp4a14^tm1Jhc
Targeted Allele Detail

Summary

• Symbol: Cyp4a14^tm1Jhc
• Name: cytochrome P450, family 4, subfamily a, polypeptide 14; targeted mutation 1, Jorge H Capdevila
• MGI ID: MGI:2183240
• Synonyms: 4a14(-)
• Gene: Cyp4a14 Location: Chr4:115343397-115353339 bp, - strand Genetic Position: Chr4, 53.04 cM
• Alliance: Cyp4a14^tm1Jhc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77631
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 10 and 11, encoding the heme-binding domain, were replaced with a neomycin selection cassette. The insertion introduced a frameshift mutation at codon 404 and generated a unique HindIII restriction site. (J:77631)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cyp4a14 Mutation: 42 strains or lines available

References

• Original: J:77631 Holla VR, et al., Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension. Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5211-6
• All: 8 reference(s)