Clcn2^tm1Mlv
Targeted Allele Detail

Summary

• Symbol: Clcn2^tm1Mlv
• Name: chloride channel, voltage-sensitive 2; targeted mutation 1, James E Melvin
• MGI ID: MGI:2183262
• Synonyms: ClC-2^-, Clcn2^-
• Gene: Clcn2 Location: Chr16:20521714-20536496 bp, - strand Genetic Position: Chr16, 12.5 cM
• Alliance: Clcn2^tm1Mlv page

Retinal degeneration in Clcn2^tm1Mlv/Clcn2^tm1Mlv mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77673
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A portion of exon 1 and all of exon 2 were replaced with a neomycin selection cassette. Northern blot and Western blot analysis verified the absence of transcript and protein in homozygous mutant mice. (J:77673)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clcn2 Mutation: 40 strains or lines available

Notes

ES cell line = KG.

References

• Original: J:77673 Nehrke K, et al., Loss of hyperpolarization-activated Cl(-) current in salivary acinar cells from Clcn2 knockout mice. J Biol Chem. 2002 Jun 28;277(26):23604-11
• All: 14 reference(s)