Calr^tm1Star
Targeted Allele Detail

Summary

• Symbol: Calr^tm1Star
• Name: calreticulin; targeted mutation 1, Rene St-Arnaud
• MGI ID: MGI:2183263
• Synonyms: CRT^-
• Gene: Calr Location: Chr8:85568717-85573560 bp, - strand Genetic Position: Chr8, 41.21 cM
• Alliance: Calr^tm1Star page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61550
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a reverse-facing PGK-neo cassette into exon 1 via homologous recombination. Southern blot analysis detected homozygous mutant embryos up to E14.5. Western blot analysis of E14.5 homozygous mutant embryos verified the absence of gene expression. (J:61550)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Calr Mutation: 14 strains or lines available

References

• Original: J:61550 Rauch F, et al., Heart, brain, and body wall defects in mice lacking calreticulin. Exp Cell Res. 2000 Apr 10;256(1):105-11
• All: 2 reference(s)