Fancg^tm1Ada
Targeted Allele Detail

Summary

• Symbol: Fancg^tm1Ada
• Name: Fanconi anemia, complementation group G; targeted mutation 1, Alan D'Andrea
• MGI ID: MGI:2183264
• Synonyms: Fancg^-
• Gene: Fancg Location: Chr4:43002343-43010506 bp, - strand Genetic Position: Chr4, 22.97 cM, cytoband B1
• Alliance: Fancg^tm1Ada page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72945
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-9 were replaced with an FRT-flanked neo cassette via homologous recombination. The targeting vector introduces stop codons in all 3 reading frames. Gene transcripts were absent in testes from homozygous mutant animals as assayed by RT-PCR analysis using primers to exons 5 and 6. (J:72945)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Fancg^tm1Ada

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fancg Mutation: 37 strains or lines available

References

• Original: J:72945 Yang Y, et al., Targeted disruption of the murine Fanconi anemia gene, Fancg/Xrcc9. Blood. 2001 Dec 1;98(12):3435-40
• All: 9 reference(s)