Lrp5^tm1Kry
Targeted Allele Detail

Summary

• Symbol: Lrp5^tm1Kry
• Name: low density lipoprotein receptor-related protein 5; targeted mutation 1, Gerard Karsenty
• MGI ID: MGI:2183279
• Synonyms: Lrp5^-, Lrp5^lacZ
• Gene: Lrp5 Location: Chr19:3634828-3736564 bp, - strand Genetic Position: Chr19, 3.33 cM, cytoband B
• Alliance: Lrp5^tm1Kry page

Low bone mass in Lrp5^tm1Kry/Lrp5^tm1Kry mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75973
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The extracellular domain of the gene was disrupted by insertion of an IRES-lacZ-neo cassette at codon 373 via homologous recombination. The targeted mutation resembles a mutation found in patients with osteoporosis-pseudoglioma syndrome. Northern blot analysis of livers from homozygous mutant animals did not detect gene transcripts using a probe to exons 10-12, but a probe to exons 1-2 detected a truncated transcript. Immunohistochemistry detected a truncated protein in osteoblasts of homozygous mutants. (J:75973)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrp5 Mutation: 82 strains or lines available

References

• Original: J:75973 Kato M, et al., Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J Cell Biol. 2002 Apr 15;157(2):303-14
• All: 19 reference(s)