Pten^tm1Mro
Targeted Allele Detail

Summary

• Symbol: Pten^tm1Mro
• Name: phosphatase and tensin homolog; targeted mutation 1, Silvia Marino
• MGI ID: MGI:2183284
• Synonyms: Pten^fl, Pten^flox, Pten^fx, Pten^LoxP
• Gene: Pten Location: Chr19:32734977-32803560 bp, + strand Genetic Position: Chr19, 28.14 cM
• Alliance: Pten^tm1Mro page

Prostate cancer progression in Tg(Pbsn-cre)4Prb/0 Gt(ROSA)26Sor^{tm1(CAG-Bmi1,-EGFP)Nki}/Gt(ROSA)26Sor⁺, Tg(Pbsn-cre)4Prb/0 Pten^tm1Mro/Pten⁺, and Tg(Pbsn-cre)4Prb/0 Gt(ROSA)26Sor^{tm1(CAG-Bmi1,-EGFP)Nki}/Gt(ROSA)26Sor⁺ Pten^tm1Mro/Pten⁺ mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77123
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector which contained a floxed neomycin selection cassette in intron 4 and a loxP site in intron 5 was electroporated into ES cells that were subsequently transiently transfected with a cre recombinase expression plasmid. The expression of cre resulted in the excision of the neo transgene, leaving exon 5 flanked by loxP sites. Mice carrying this allele were used to generate Pten^tm1.1. (J:77123)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Pten^tm1Mro

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pten Mutation: 88 strains or lines available

References

• Original: J:77123 Marino S, et al., PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum. Development. 2002 Jul;129(14):3513-22
• All: 40 reference(s)