Gstz1^tm1Jmfc
Targeted Allele Detail

Summary

• Symbol: Gstz1^tm1Jmfc
• Name: glutathione transferase zeta 1 (maleylacetoacetate isomerase); targeted mutation 1, Jose Manuel Fernandez-Canon
• MGI ID: MGI:2183286
• Synonyms: MAAI-deficient, MAAI-KO
• Gene: Gstz1 Location: Chr12:87193939-87211497 bp, + strand Genetic Position: Chr12, 41.34 cM, cytoband E
• Alliance: Gstz1^tm1Jmfc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77040
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The majority of the coding region (exons 4-9) was replaced with a neomycin resistance gene via homologous recombination. Western blot analysis of kidney and liver extracts from homozygous mutant animals did not detect gene expression. Enzyme activity was absent in liver extracts from homozygous mutant animals. (J:77040)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gstz1 Mutation: 23 strains or lines available

References

• Original: J:77040 Fernandez-Canon JM, et al., Maleylacetoacetate isomerase (MAAI/GSTZ)-deficient mice reveal a glutathione-dependent nonenzymatic bypass in tyrosine catabolism. Mol Cell Biol. 2002 Jul;22(13):4943-51
• All: 6 reference(s)