Cyp26a1^tm1.1Hmd
Targeted Allele Detail

Summary

• Symbol: Cyp26a1^tm1.1Hmd
• Name: cytochrome P450, family 26, subfamily a, polypeptide 1; targeted mutation 1.1, Hiroshi Hamada
• MGI ID: MGI:2183292
• Synonyms: CYP26-
• Gene: Cyp26a1 Location: Chr19:37686246-37689984 bp, + strand Genetic Position: Chr19, 32.36 cM, cytoband C2-C3
• Alliance: Cyp26a1^tm1.1Hmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67375
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele is a derivative of Cyp26a1^tm1Hmd in which the loxP flanked sequences were deleted in ES cells prior to the production of chimeric mice. All coding sequences of the gene were deleted. (J:67375)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Cyp26a1 Mutation: 33 strains or lines available

References

• Original: J:67375 Sakai Y, et al., The retinoic acid-inactivating enzyme CYP26 is essential for establishing an uneven distribution of retinoic acid along the anterio-posterior axis within the mouse embryo. Genes Dev. 2001 Jan 15;15(2):213-25
• All: 6 reference(s)