Ugt8a^tm1Pop
Targeted Allele Detail

Summary

• Symbol: Ugt8a^tm1Pop
• Name: UDP galactosyltransferase 8A; targeted mutation 1, Brian Popko
• MGI ID: MGI:2183312
• Synonyms: Cgt-, Cgt⁰, CGT^null
• Gene: Ugt8a Location: Chr3:125658920-125732268 bp, - strand Genetic Position: Chr3, 54.68 cM, cytoband E3-F1
• Alliance: Ugt8a^tm1Pop page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77226
• Parent Cell Line: BK4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 2 was disrupted by the insertion of a neomycin selection cassette 219 base pairs downstream of the translational start codon. Northern blot analyses showed the exclusive presence of truncated transcript containing the neo transgene in homozgous mutant mice. (J:77226)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ugt8a Mutation: 28 strains or lines available

References

• Original: J:77226 Coetzee T, et al., Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability. Cell. 1996 Jul 26;86(2):209-19
• All: 26 reference(s)