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Cebpatm1.1(Cebpb)Ylee
Targeted Allele Detail
Summary
Symbol: Cebpatm1.1(Cebpb)Ylee
Name: CCAAT/enhancer binding protein alpha; targeted mutation 1.1, Ying-Hue Lee
MGI ID: MGI:2183333
Synonyms: C/ebpa-alphabeta
Gene: Cebpa  Location: Chr7:34818718-34821353 bp, + strand  Genetic Position: Chr7, 21.02 cM
Alliance: Cebpatm1.1(Cebpb)Ylee page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77646
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence, Null/knockout)
Mutation:    Insertion
 
Cebpatm1.1(Cebpb)Ylee expresses 1 gene
 
Mutation detailsThis allele was generated by breeding mice homozygous for Cebpatm1(Cebpb)Ylee with transgenic mice expressing cre recombinase, driven by the EIIa promoter. Expression of cre resulted in the excision of the floxed neo gene downstream of the stop codon. The Cebpb coding region inserted at the endogenous start codon to replace the coding region of Cebpa remained intact. Northern blot analysis confirmed the absence of Cebpa mRNA and the presence of the Cebpa/Cebpb hybrid mRNA in homozygous mutant mice. Western blot analysis showed that Cebpb protein levels were concomitant with the combined amount of Cebpb and Cebpa/Cebpb transcript until the age of 7 weeks. (J:77646)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cebpa Mutation:  19 strains or lines available
References
Original:  J:77646 Chen SS, et al., C/EBPbeta, when expressed from the C/ebpalpha gene locus, can functionally replace C/EBPalpha in liver but not in adipose tissue. Mol Cell Biol. 2000 Oct;20(19):7292-9
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory