Ktn1^tm1.1Kpf
Targeted Allele Detail

Summary

• Symbol: Ktn1^tm1.1Kpf
• Name: kinectin 1; targeted mutation 1.1, Klaus Pfeffer
• MGI ID: MGI:2183361
• Synonyms: knt^F
• Gene: Ktn1 Location: Chr14:47886551-47974021 bp, + strand Genetic Position: Chr14, 24.6 cM, cytoband C2
• Alliance: Ktn1^tm1.1Kpf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77650
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: This allele was generated by transient transfection of ES cells harboring Ktn^tm1Kpf with a cre expression plasmid. The excision of neomycin was mediated by the expression of cre, leaving exons 3 through 5 flanked by loxP sites. Encoded protein was detected in homozygous mutant mice via Western blot analysis. (J:77650)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ktn1 Mutation: 76 strains or lines available

References

• Original: J:77650 Plitz T, et al., Intact lysosome transport and phagosome function despite kinectin deficiency. Mol Cell Biol. 2001 Sep;21(17):6044-55
• All: 1 reference(s)