Runx3^tm1Yg
Targeted Allele Detail

Summary

• Symbol: Runx3^tm1Yg
• Name: runt related transcription factor 3; targeted mutation 1, Yoram Groner
• MGI ID: MGI:2183399
• Synonyms: Rehovot-Runx3^Lacz, Runx3-, Runx3^LacZ
• Gene: Runx3 Location: Chr4:134847963-134905301 bp, + strand Genetic Position: Chr4, 67.19 cM
• Alliance: Runx3^tm1Yg page

Pathological findings in large intestines of Runx3^tm1Yg/Runx3^tm1Yg and +/+ wild-type.

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77764
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Exon 2, encoding the runt domain, was disrupted by the insertion of a cassette containing IRES-lacZ and neo. RT-PCR analysis of dorsal root ganglia RNA extracts showed an absence of transcript in homozygous mutant mice. Protein was undetected by Western blot analysis of thymus tissue and immunostaining of dorsal root ganglia. Expression of beta-galactosidase was visualized in mutant embryos via X-gal staining. (J:77764)

Disease models

Expression

In Mice Carrying this Mutation:	38 assay results
In Structures Affected by this Mutation:	34 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Runx3 Mutation: 27 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Osteopenia, Congenital J:224290 in homozygotes.

References

• Original: J:77764 Levanon D, et al., The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons. EMBO J. 2002 Jul 1;21(13):3454-63
• All: 26 reference(s)